Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates.
The continued spread of highly pathogenic H5N1 influenza viruses among poultry and wild birds, together with the emergence of drug-resistant variants and the possibility of human-to-human transmission, has spurred attempts to develop an effective vaccine.Inactivated subvirion or whole-virion H5N1 vaccines have shown promising immunogenicity in clin